Spatial metabolomics technology for life science and medicine

Prasad Phapale

Prasad Phapale

Metabolomics technologies have proved their potential in early disease diagnosis and monitoring health conditions. This has also opened a new window into understanding the biochemistry of health and diseases such as cancers, cardiovascular disease, and other metabolic disorders. With recent advances in mass spectrometry imaging and computational methods, metabolites and lipids can be mapped at single-cell resolution from any tissue sections, organoids, and cell culture models. This emerging field of spatial metabolomics is complementing our spatial molecular understanding with a new dimension. The ability to label-free profiling 100s of metabolites from a biological system can provide unprecedented molecular insights into pathophysiological mechanisms with new therapeutic options for previously unmet medical conditions. In my talk, I will review the recent advances in metabolomics technologies and how they are shaping medical diagnosis as well as contributing to our molecular and spatial understanding of new biochemical pathways. The talk will also provide an overview of the potential of our latest MALDI imaging technology with post-ionization for comprehensive metabolite imaging.

 

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