Interactions between DNA repair and transcription

Ingrid Tessmer

Ingrid Tessmer

The base excision repair (BER) glycosylase hOGG1 (human oxoguanine glycosylase 1) is responsible for repairing oxidative lesions in the genome, in particular oxidised guanine bases (oxoG). In addition, a role of hOGG1 in transcription regulation by recruitment of various transcription factors has been reported. Here, we investigate the mechanism of recruitment of the medically important oncogene transcription factor Myc that is involved in transcription initiation of a large number of genes including inflammatory genes, by hOGG1 under oxidative stress conditions using single molecule atomic force microscopy (AFM) in combination with biophysical and biochemical assays.

 

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